Source:http://www.reactome.org/biopax/48887BiochemicalReaction1037
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Authored: D'Eustachio, P, 2005-02-14 18:06:15,
Edited: D'Eustachio, P, 0000-00-00 00:00:00,
Plasminogen, tethered to the cell surface by its association with histidine-rich glycoprotein, is rapidly cleaved and activated to plasmin by the action of urokinase plasminogen activator(two-chain form) bound to uPAR, its cell-surface receptor. The association of both substrate and enzyme with the cell surface is necessary for the reaction to proceed efficiently (Ellis et al. 1989, 1991).
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plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
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3.4.21
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