Source:http://www.reactome.org/biopax/48887BiochemicalReaction1022
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Authored: D'Eustachio, P, 2005-02-05 20:25:20,
Edited: D'Eustachio, P, 0000-00-00 00:00:00,
Plasminogen reversibly binds histidine-rich glycoprotein (HRG). The resulting complex interacts poorly with fibrin, suggesting that HRG might have an anti-fibrinolytic (clot-stabilizing) effect in vivo (Lijnen et al. 1980). Consistent with this suggestion, individuals with chronically reduced plasma HRG concentrations are susceptible to thrombosis (Shigekiyo et al. 1998).
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histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen
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