Source:http://www.reactome.org/biopax/48887BiochemicalReaction102
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Authored: Orlic-Milacic, M, 2012-04-04,
Edited: Jassal, B, 2012-04-10,
PARP1 ADP-ribosylates SMAD3 and SMAD4 in SMAD2/3:SMAD4 heterotrimer. ADP-ribosyl group is attached to glutamic acid residues E50 and E52 of SMAD3 and unknown amino acid residues of SMAD4. ADP-ribose monomer attached to SMAD3 and SMAD4 is subsequently extended to poly (ADP-ribosyl) chains (i.e. PAR chains) by PARP1, which is not shown here. ADP-ribosylation (PARylation) of SMAD3 and SMAD4 by PARP1 inhibits binding of SMAD2/3:SMAD4 heterotrimers to SMAD binding elements (SBEs) in promoters of SMAD-target genes.,
Reviewed: Huang, Tao, 2012-05-14
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PARP1 ADP-ribosylates SMAD3 and SMAD4
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2.4.2.30
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