Viral protein involved in host immune evasion thereby optimizing viral growth and dissemination. Viral immune evasion strategies are typical of viruses which persist in their host throughout life. For example: Herpesviridae, Adenoviridae, Poxviridae and Retroviridae have developed subversions of the MHC class I antigen-presentation pathway. In order to reduce the effectiveness of cytotoxic T-lymphocytes immunity, they express proteins that either down-modulate MHC class I expression (degradation or mislocalization) or interfere with the antigen binding/presentation process (down-regulation of the expression of the transporter associated with antigen processing TAP). Some proteins of these virus families also down-regulate other molecules involved in immune recognition.
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rdf:type | |
rdfs:comment |
Viral protein involved in host immune evasion thereby optimizing viral growth and dissemination. Viral immune evasion strategies are typical of viruses which persist in their host throughout life. For example: Herpesviridae, Adenoviridae, Poxviridae and Retroviridae have developed subversions of the MHC class I antigen-presentation pathway. In order to reduce the effectiveness of cytotoxic T-lymphocytes immunity, they express proteins that either down-modulate MHC class I expression (degradation or mislocalization) or interfere with the antigen binding/presentation process (down-regulation of the expression of the transporter associated with antigen processing TAP). Some proteins of these virus families also down-regulate other molecules involved in immune recognition.
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rdfs:subClassOf | |
rdfs:label |
Immunoevasin,
Viral host defense evasion,
Viral immune evasion,
Viral immunoevasion
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rdfs:seeAlso | |
skos:narrower |
http://purl.uniprot.org/keywords/1080,
http://purl.uniprot.org/keywords/1086,
http://purl.uniprot.org/keywords/1087,
http://purl.uniprot.org/keywords/1090,
http://purl.uniprot.org/keywords/1118,
http://purl.uniprot.org/keywords/1124,
http://purl.uniprot.org/keywords/1125,
http://purl.uniprot.org/keywords/1131
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uniprot:category |