Protein involved in the synthesis of streptomycin, an antibiotic substance produced by the soil actinomycete Streptomyces griseus. The three parts of the molecule (streptidine-6-P, dTDP-dihydrostreptose and N-methyl-glucosamine) are synthesized by separate biochemical pathways and the subunits brought together at the end. The final intermediate in the pathway, streptomycin P, becomes biologically active upon removal of the phosphate. The synthesis of the key streptomycin biosynthesis enzymes is mainly regulated by differing levels of factor A. Streptomycin binds to the small subunit of ribosomes of prokaryotic cells and causes inhibition and misreading.
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Protein involved in the synthesis of streptomycin, an antibiotic substance produced by the soil actinomycete Streptomyces griseus. The three parts of the molecule (streptidine-6-P, dTDP-dihydrostreptose and N-methyl-glucosamine) are synthesized by separate biochemical pathways and the subunits brought together at the end. The final intermediate in the pathway, streptomycin P, becomes biologically active upon removal of the phosphate. The synthesis of the key streptomycin biosynthesis enzymes is mainly regulated by differing levels of factor A. Streptomycin binds to the small subunit of ribosomes of prokaryotic cells and causes inhibition and misreading.
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Streptomycin biosynthesis
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