The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
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The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
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(4-aminobutyl)lysine synthase activity,
[eIF-5A]-deoxyhypusine synthase activity,
deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase,
deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase,
deoxyhypusine biosynthetic process from spermidine,
deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase,
deoxyhypusine formation from spermidine, using deoxyhypusine synthase,
spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase,
spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase,
spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
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