Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.
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Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.
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17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity,
20alpha-HSD,
20alpha-HSDH,
20alpha-hydroxy steroid dehydrogenase activity,
20alpha-hydroxysteroid dehydrogenase,
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity
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