The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. The cascade begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
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| rdfs:comment |
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. The cascade begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
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| rdfs:subClassOf | |
| rdfs:label |
NIK/NF-kappaB cascade,
non-canonical NF-KB signaling,
noncanonical NF-kappaB signaling,
noncanonical nuclear factor kappaB (NF-kappaB) pathway,
p52-dependent NF-kappaB signaling
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| skos:exactMatch | |
| skos:narrower |