The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
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| rdfs:subClassOf | |
| rdfs:label |
I-kappaB phosphorylation,
IKB phosphorylation,
IkappaB phosphorylation,
inhibitor of NF-kappaB phosphorylation,
inhibitor of kappaB phosphorylation
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| skos:exactMatch |