Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
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Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
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1-hydroxylase-25-hydroxyvitamin D3 activity,
25-OHD-1 alpha-hydroxylase activity,
25-hydroxy D3-1alpha-hydroxylase activity,
25-hydroxy vitamin D3 1-alpha-hydroxylase activity,
25-hydroxycholecalciferol 1-hydroxylase activity,
25-hydroxycholecalciferol 1-monooxygenase activity,
25-hydroxycholecalciferol 1alpha-hydroxylase activity,
25-hydroxycholecalciferol-1-hydroxylase activity,
25-hydroxyvitamin D-1 alpha hydroxylase activity,
25-hydroxyvitamin D3 1alpha-hydroxylase activity,
calcidiol 1-monooxygenase activity,
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating),
cytochrome P450 CYP27B
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