Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
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Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
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DNA glycosylase/AP-lyase,
DNA glycosylase/beta-lyase,
bifunctional DNA glycosylase,
endodeoxyribonuclease III,
endonuclease III,
endonuclease VIII activity,
oxidized pyrimidine base lesion DNA N-glycosylase activity,
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity,
pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
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