This enzyme, which forms part of the aerobic cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP-dependent.
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ATP can be replaced by dATP or CTP but the reaction proceeds more slowly.,
CobN exhibits a high affinity for hydrogenobyrinic acid a,c-diamide.,
Hydrogenobyrinic acid is a very poor substrate.,
It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST.,
Once the Co(2+) is inserted, the next step in the pathway ensures that the cobalt is ligated securely by reducing Co(II) to Co(I); this step is carried out by EC 1.16.8.1.,
The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding.,
This enzyme, which forms part of the aerobic cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP-dependent.
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| uniprot:name |
Cobaltochelatase,
Hydrogenobyrinic acid a,c-diamide cobaltochelatase
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| uniprot:activity |
ATP + hydrogenobyrinic acid a,c-diamide + Co(2+) + H(2)O = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H(2).
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