This amidase catalyzes the last step in the conversion of an L-histidine residue in the translation elongation factor eEF-2 to diphthamide.
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| rdf:type | |
| rdfs:comment |
The nature of the ammonia donor is not known.,
The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98.,
This amidase catalyzes the last step in the conversion of an L-histidine residue in the translation elongation factor eEF-2 to diphthamide.,
This factor is found in all archaebacteria and eukaryotes, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36).
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| uniprot:name |
Diphthamide synthase,
Diphthamide synthetase,
Diphthine--ammonia ligase
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| uniprot:replaces | |
| uniprot:activity |
ATP + diphthine + NH(3) = ADP + phosphate + diphthamide.
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