Degrades a variety of glycosaminoglycans of the chondroitin-sulfate-and dermatan-sulfate type.
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Both enzymes act by the removal of a relatively acidic C-5 proton of the uronic acid followed by the elimination of a 4-linked hexosamine, resulting in the formation of an unsaturated C4-C5 bond on the hexuronic acid moiety of the products.,
Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate.,
Degrades a variety of glycosaminoglycans of the chondroitin-sulfate-and dermatan-sulfate type.,
The related enzyme EC 4.2.2.20 has the same substrate specificity but produces a mixture of oligosaccharides of different sizes that are ultimately degraded to tetra-and disaccharides.
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| uniprot:name |
ChS ABC lyase,
ChS ABC lyase II,
Chondroitin ABC eliminase,
Chondroitin ABC lyase,
Chondroitin sulfate ABC exoeliminase,
Chondroitin sulfate ABC exolyase,
Chondroitin sulfate ABC lyase,
Chondroitin-sulfate-ABC exolyase,
Chondroitinase,
Chondroitinase ABC
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| uniprot:activity |
Exolytic removal of Delta(4)-unsaturated disaccharide residues from the non-reducing ends of both polymeric chondroitin/dermatan sulfates and their oligosaccharide fragments.
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