In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region.
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Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source.,
Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate.,
Degrades a variety of glycosaminoglycans of the chondroitin-sulfate-and dermatan-sulfate type.,
GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of DS.,
In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region.,
Keratan sulfate, heparan sulfate and heparin are not substrates.,
The related enzyme EC 4.2.2.21 has the same substrate specificity but removes disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments produced by EC 4.2.2.20.,
The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1-3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA.
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ChS ABC lyase,
ChS ABC lyase I,
Chondroitin ABC eliminase,
Chondroitin ABC lyase,
Chondroitin sulfate ABC endoeliminase,
Chondroitin sulfate ABC endolyase,
Chondroitin sulfate ABC lyase,
Chondroitin-sulfate-ABC endolyase,
Chondroitinase,
Chondroitinase ABC
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Endolytic cleavage of (1->4)-beta-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta(4)-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta(4)-unsaturated tetra- and disaccharides.
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