Catalyzes several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Catalyzes several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.,
Cis-aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme.,
In addition to cis-homoaconitate, the enzyme can also catalyze the hydration of the physiological substrates dihomocitrate and trihomocitrate as well as the non-physiological substrate tetrahomocitrate.,
In contrast to EC 4.2.1.36, this enzyme can catalyze both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Methanogen HACN,
Methanogen homoaconitase
|
| uniprot:activity |
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate.
|
| uniprot:cofactor |
Iron-sulfur
|