Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.,
In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate.,
Is also able to catalyze the aldol cleavage of 4-hydroxy-2-ketopentanoate and 4-hydroxy-2-ketohexanoate, and exhibits significant oxaloacetate decarboxylase activity in vitro.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase,
4-hydroxy-2-ketoheptane-1,7-dioate aldolase,
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase,
HHED aldolase,
HKHD aldolase
|
| uniprot:activity |
4-hydroxy-2-ketoheptane-1,7-dioate = pyruvate + succinate semialdehyde.
|
| uniprot:cofactor |
Manganese or cobalt
|