A 20-S protein composed of 28 subunits arranged in four rings of seven.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
A 20-S protein composed of 28 subunits arranged in four rings of seven.,
Belongs to peptidase family T1.,
In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities.,
Inhibited by mercurial reagents and some inhibitors of serine endopeptidases.,
Terminal apertures restrict access of substrates to the active sites.,
The molecule is barrel-shaped, and the active sites are on the inner surfaces.,
The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Ingensin,
Lens neutral proteinase,
Macropain,
Multicatalytic endopeptidase complex,
Multicatalytic proteinase (complex),
Prosome,
Proteasome,
Proteasome endopeptidase complex
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| uniprot:replaces | |
| uniprot:activity |
Cleavage of peptide bonds with very broad specificity.
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