Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor.,
Belongs to peptidase family C14.,
Caspase-11 plays a critical role in the activation of caspase-1 in mice whereas caspase-4 enhances its activation in humans.,
Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1-beta, a potent mediator of inflammation.,
Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.,
Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.,
Part of the family of inflammatory-caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Caspase-1,
Interleukin 1-beta converting enzyme,
Interleukin 1-beta-converting endopeptidase,
Interleukin-1 beta convertase precursor,
Interleukin-1-beta convertase,
Pro-interleukin 1-beta proteinase,
Prointerleukin 1-beta protease
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| uniprot:activity |
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
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