These endopeptidases are multi-spanning membrane proteins.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Belongs to peptidase family S54.,
Important for embryo development in Drosophila melanogaster.,
Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.,
Rhomboid is a key regulator of EGF receptor signaling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway.,
Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains.,
These endopeptidases are multi-spanning membrane proteins.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Rhomboid protease
|
| uniprot:activity |
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
|