Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms.
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Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.,
Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms.
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| uniprot:name |
Uracil DNA glycohydrolase,
Uracil-DNA N-glycosylase,
Uracil-DNA glycosylase
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| uniprot:activity |
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
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