Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Cf. EC 2.7.1.172.,
Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins.,
Key early intermediates in this process are fructosamines, such as [protein]-N(6)-D-fructosyl-L-lysine.,
Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications.,
The phosphorylation destablilizes the [protein]-N(6)-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Fructosamine 3-kinase,
Protein-fructosamine 3-kinase
|
| uniprot:activity |
ATP + [protein]-N(6)-D-fructosyl-L-lysine = ADP + [protein]-N(6)-(3-O-phospho-D-fructosyl)-L-lysine.
|