Catalyzes the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Also catalyzes the third step in the biosynthesis of the coenzyme pyridoxal 5'-phosphate in E.coli (using reaction 2 above).,
Catalyzes the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli.,
In E.coli, pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate).,
Non-phosphorylated forms of serine and threonine are not substrates.,
Pyridoxal phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
3-phosphoserine aminotransferase,
3PHP transaminase,
Hydroxypyruvic phosphate--glutamic transaminase,
L-phosphoserine aminotransferase,
PSAT,
Phosphohydroxypyruvate transaminase,
Phosphohydroxypyruvic--glutamic transaminase,
Phosphoserine aminotransferase,
Phosphoserine transaminase
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| uniprot:activity |
(1) O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.,
(2) 4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.
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| uniprot:cofactor |
Pyridoxal 5'-phosphate
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