This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.,
Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.,
Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP).,
This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
GGTaseII,
Protein geranylgeranyltransferase type II,
Rab geranylgeranyltransferase,
RabGGTase,
Type II protein geranyl-geranyltransferase
|
| uniprot:activity |
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
|