Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.
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| rdf:type | |
| rdfs:comment |
Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34.,
In eubacteria, which produce queuine de novo, the enzyme catalyzes the exchange of guanine with the queuine precursor preQ(1), which is ultimately modified to queuine.,
In eukaryotes queuine is salvaged from food and incorporated into tRNA directly via a base-exchange reaction, replacing guanine.,
The eubacterial enzyme can also use an earlier intermediate, preQ(0), to replace guanine in unmodified tRNA(Tyr) and tRNA(Asn).,
This enzyme acts after EC 1.7.1.13 in the queuine-biosynthesis pathway.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Guanine insertion enzyme,
Q-insertase,
Queuine tRNA-ribosyltransferase,
Queuine(34) transfer ribonucleate ribosyltransferase,
TGT,
tRNA guanine(34) transglycosidase,
tRNA transglycosylase,
tRNA-guanine(34) transglycosylase
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| uniprot:activity |
(1) Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine.,
(2) Guanine(34) in tRNA + 7-aminomethyl-7-carbaguanine = 7-aminomethyl-7-carbaguanine(34) in tRNA + guanine.
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