Chondroitin synthase

Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.

Source:http://purl.uniprot.org/enzyme/2.4.1.175

Statements in which the resource exists as a subject.
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Involved in the biosynthesis of chondroitin sulfate., Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli., The human form of this enzyme is a bifunctional glycosyltransferase, which also has the EC 2.4.1.226 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
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uniprot:name
Chondroitin synthase, Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase, Glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, Uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II
uniprot:activity
UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan.