Peptidoglycan TGase

Involved in the synthesis of cell-wall peptidoglycan.

Source:http://purl.uniprot.org/enzyme/2.4.1.129

Statements in which the resource exists as a subject.
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rdfs:comment
Involved in the synthesis of cell-wall peptidoglycan., The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-center, as it is in Gram-negative and some Gram-positive organisms., The undecaprenol involved is ditrans,octacis-undecaprenol.
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uniprot:name
Bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase, PG-II, Penicillin binding protein (3 or 1B), Peptidoglycan TGase, Peptidoglycan glycosyltransferase, Peptidoglycan transglycosylase
uniprot:activity
(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.