3-oxoacyl-[acyl-carrier-protein] synthase

Responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain.

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Predicate	Object
rdf:type	uniprot:Enzyme
rdfs:comment	Can use fatty acyl thioesters of ACP (C(2) to C(16)) as substrates, as well as fatty acyl thioesters of Co-A (C(4) to C(16))., Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids., Responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain., The substrate specificity is very similar to that of EC 2.3.1.179 with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C(16)-Delta(9)) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature.
rdfs:subClassOf	http://purl.uniprot.org/enzyme/2.3.1.-
skos:broaderTransitive	http://purl.uniprot.org/enzyme/2.3.1.-
uniprot:name	3-ketoacyl-acyl carrier protein synthase, 3-oxoacyl-[acyl-carrier-protein] synthase, Acyl-malonyl acyl carrier protein-condensing enzyme, Acyl-malonyl(acyl-carrier-protein)-condensing enzyme, Beta-ketoacyl acyl carrier protein synthase, Beta-ketoacyl synthetase, Beta-ketoacyl-ACP synthase I, Beta-ketoacyl-ACP synthetase, Beta-ketoacyl-[acyl carrier protein] synthase, Beta-ketoacyl-[acyl-carrier-protein] synthase I, Beta-ketoacyl-acyl carrier protein synthetase, Beta-ketoacylsynthase, Condensing enzyme, Fatty acid condensing enzyme, KAS I
uniprot:activity	Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].