This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
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Cf. EC 1.1.1.330, EC 4.2.1.134 and EC 1.3.1.93.,
For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate, while CER6 from the same plant prefers substrates with chain length of C(22) to C(32).,
Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids.,
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
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| uniprot:name |
Condensing enzyme,
Very-long-chain 3-ketoacyl-CoA synthase,
Very-long-chain 3-oxoacyl-CoA synthase,
Very-long-chain beta-ketoacyl-CoA synthase
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| uniprot:activity |
A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
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