The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine(1920) in helix 69 of 23S rRNA and cytidine(1409) in helix 44 of 16S rRNA (cf. EC 2.1.1.227).
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The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine(1920) in helix 69 of 23S rRNA and cytidine(1409) in helix 44 of 16S rRNA (cf. EC 2.1.1.227).,
These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin.
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23S rRNA (cytidine(1920)-2'-O)-methyltransferase
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S-adenosyl-L-methionine + cytidine(1920) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(1920) in 23S rRNA.
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