| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
All thymidylate synthases catalyze a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5-position of dUMP and a two electron reduction of the methylene group to a methyl group.,
Contains FAD.,
Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin coenzyme as a source of reducing equivalents, which are derived from NADPH.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
FDTS,
Flavin dependent thymidylate synthase,
Thymidylate synthase (FAD)
|
| uniprot:activity |
5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP(+).
|