The reaction occurs in the reverse direction to that shown above.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Exhibits high specificity for reduction of the R-form of methionine S-oxide, with higher activity being observed with L-methionine S-oxide than with D-methionine S-oxide.,
For MsrB2 and MsrB3, thioredoxin is a poor reducing agent but thionein works well.,
Plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged.,
The reaction occurs in the reverse direction to that shown above.,
The reaction proceeds via a sulfenic-acid intermediate.,
While both free and protein-bound methionine (R)-S-oxide act as substrates, the activity with the peptide-bound form is far greater.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Methionine S-oxide reductase,
Methionine S-oxide reductase (R-form oxidizing),
Methionine sulfoxide reductase,
Methionine sulfoxide reductase B,
Peptide-methionine (R)-S-oxide reductase,
Selenoprotein R
|
| uniprot:activity |
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.
|
| uniprot:cofactor |
Selenium,
Zinc
|