The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
A component of the multienzyme 2-oxo-acid dehydrogenase complexes.,
Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.,
In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.,
It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.,
It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes.,
The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.,
Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Dehydrolipoate dehydrogenase,
Diaphorase,
Dihydrolipoamide dehydrogenase,
Dihydrolipoic dehydrogenase,
Dihydrolipoyl dehydrogenase,
Dihydrothioctic dehydrogenase,
E3 component of alpha-ketoacid dehydrogenase complexes,
Glycine-cleavage system L-protein,
L-protein,
LDP-Glc,
LDP-Val,
Lipoamide dehydrogenase (NADH),
Lipoamide oxidoreductase (NADH),
Lipoamide reductase,
Lipoamide reductase (NADH),
Lipoate dehydrogenase,
Lipoic acid dehydrogenase,
Lipoyl dehydrogenase
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| uniprot:replaces | |
| uniprot:activity |
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
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| uniprot:cofactor |
FAD
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