This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.,
Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but 1-and 3-methyl and 1,3-dimethyl methyl-(S)-dihydroorotates are not.,
The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates.,
The enzyme is found in eukaryotes in the mitochondrial membrane, and in some Gram negative bacteria associated with the cytoplasmic membrane.,
The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.,
This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
DHOD,
DHODH,
DHOdehase,
Dihydroorotate dehydrogenase (quinone)
|
| uniprot:replaces | |
| uniprot:activity |
(S)-dihydroorotate + a quinone = orotate + a quinol.
|
| uniprot:cofactor |
FMN
|