In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.
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| rdf:type | |
| rdfs:comment |
Catalyzes the second of three steps leading to the formation of siroheme from uroporphyrinogen III.,
In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.,
In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction.,
The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4).
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
Precorrin-2 dehydrogenase,
Precorrin-2 oxidase
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| uniprot:activity |
Precorrin-2 + NAD(+) = sirohydrochlorin + NADH.
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