It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.,
It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
2-ketoglutarate dehydrogenase,
2-oxoglutarate dehydrogenase,
2-oxoglutarate: lipoate oxidoreductase,
2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating),
AKGDH,
Alpha-ketoglutarate dehydrogenase,
Alpha-ketoglutaric acid dehydrogenase,
Alpha-ketoglutaric dehydrogenase,
Alpha-oxoglutarate dehydrogenase,
Ketoglutaric dehydrogenase,
OGDC,
Oxoglutarate decarboxylase,
Oxoglutarate dehydrogenase,
Oxoglutarate dehydrogenase (lipoamide),
Oxoglutarate dehydrogenase (succinyl-transferring)
|
| uniprot:activity |
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
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| uniprot:cofactor |
Thiamine diphosphate
|