Acts on a variety of purines and aldehydes, including hypoxanthine.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Acts on a variety of purines and aldehydes, including hypoxanthine.,
During purification the enzyme is largely converted to an O(2)-dependent form, EC 1.17.3.2.,
The conversion can also occur in vivo.,
The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds (which can be catalyzed by EC 1.8.4.7 in the presence of glutathione disulfide) or limited proteolysis, which results in irreversible conversion.,
The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum center.,
The mammalian enzyme can also convert all-trans retinol to all-trans-retinoate, while the substrate is bound to a retinoid-binding protein.,
The mammallian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4).
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
NAD-xanthine dehydrogenase,
Xanthine dehydrogenase,
Xanthine oxidoreductase,
Xanthine-NAD oxidoreductase,
Xanthine/NAD(+) oxidoreductase
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| uniprot:replaces | |
| uniprot:activity |
(1) Xanthine + NAD(+) + H(2)O = urate + NADH.,
(2) Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH.
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| uniprot:cofactor |
FAD,
Iron-sulfur,
Molybdenum
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