This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain.
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| rdf:type | |
| rdfs:comment |
Cf. EC 1.14.13.165.,
May produce superoxide under certain conditions.,
This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain.,
Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center.
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| rdfs:subClassOf | |
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| uniprot:name |
Endothelium-derived relaxation factor-forming enzyme,
Endothelium-derived relaxing factor synthase,
NADPH-diaphorase,
NO synthase,
Nitric-oxide synthase (NADPH dependent),
Nitric-oxide synthetase
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| uniprot:activity |
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.
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