Catalyzes the direct beta-hydroxylation of L-asparagine to (2S,3S)-3-hydroxyasparagine.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
Catalyzes the direct beta-hydroxylation of L-asparagine to (2S,3S)-3-hydroxyasparagine.,
The beta-hydroxylated asparagine produced is incorporated at position 9 during the biosynthesis of the non-ribosomally synthesized calcium-dependent antibiotic (CDA), a 11-residue acidic lipopeptide lactone.,
The enzyme is able to hydroxylate only the free L-asparagine, since it hydroxylates neither a CDA analog with unmodified Asn at position 9 nor a peptidyl-carrier-protein (PCP)-bound asparagine.,
The enzyme is not active toward D-asparagine.
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| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
L-asparagine 3-hydroxylase,
L-asparagine oxygenase
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| uniprot:activity |
L-asparagine + 2-oxoglutarate + O(2) = (2S,3S)-3-hydroxyasparagine + succinate + CO(2).
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| uniprot:cofactor |
Iron
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