Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
It can also demethylate the monomethyl-but not the trimethyl form of Lys-36.,
Lysine residues exist in three methylation states (mono-, di-and trimethylated).,
Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36.,
The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
H3-K36-specific demethylase,
Histone demethylase,
Histone-lysine (H3-K36) demethylase,
JHDM1A,
JmjC domain-containing histone demethylase 1A,
[Histone H3]-lysine-36 demethylase
|
| uniprot:activity |
(1) Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2).,
(2) Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
|
| uniprot:cofactor |
Fe(2+)
|