Catalyzes the first committed step in the phosphoserine pathway of serine biosynthesis in Escherichia coli.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Catalyzes the first committed step in the phosphoserine pathway of serine biosynthesis in Escherichia coli.,
Reaction (1) occurs predominantly in the reverse direction and is inhibited by serine and glycine.,
The enzyme is unusual in that it also acts as a D-and L-2-hydroxyglutarate dehydrogenase (with the D-form being the better substrate) and as a 2-oxoglutarate reductase.
|
| rdfs:subClassOf | |
| skos:broaderTransitive | |
| uniprot:name |
3-phosphoglycerate dehydrogenase,
3-phosphoglyceric acid dehydrogenase,
3PHP reductase,
Alpha-KG reductase,
Alpha-phosphoglycerate dehydrogenase,
D-3-phosphoglycerate dehydrogenase,
Glycerate 3-phosphate dehydrogenase,
Glycerate-1,3-phosphate dehydrogenase,
PGDH,
Phosphoglycerate dehydrogenase,
Phosphoglycerate oxidoreductase,
Phosphoglyceric acid dehydrogenase
|
| uniprot:activity |
(1) 3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.,
(2) 2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH.
|