Mycobacteriophage D29 is a lytic phage that infects both fast and slow-growing mycobacterial species. The complete genome sequence of D29 reveals that it is a close relative of the temperate mycobacteriophage L5, whose sequence has been described previously. The overall organization of the D29 genome is similar to that of L5, although a 3.6 kb deletion removing the repressor gene accounts for the inability of D29 to form lysogens. Comparison of the two genomes shows that they are punctuated by a large number of insertions, deletions, and substitutions of genes, consistent with the genetic mosaicism of lambdoid phages.
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Mycobacteriophage D29 is a lytic phage that infects both fast and slow-growing mycobacterial species. The complete genome sequence of D29 reveals that it is a close relative of the temperate mycobacteriophage L5, whose sequence has been described previously. The overall organization of the D29 genome is similar to that of L5, although a 3.6 kb deletion removing the repressor gene accounts for the inability of D29 to form lysogens. Comparison of the two genomes shows that they are punctuated by a large number of insertions, deletions, and substitutions of genes, consistent with the genetic mosaicism of lambdoid phages.
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J. Mol. Biol.
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| uniprot:author |
Belanger A.E.,
Ford M.E.,
Hatfull G.F.,
Hendrix R.W.,
Sarkis G.J.
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| uniprot:date |
1998
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| uniprot:pages |
143-164
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| uniprot:title |
Genome structure of mycobacteriophage D29: implications for phage evolution.
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| uniprot:volume |
279
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| dc-term:identifier |
doi:10.1006/jmbi.1997.1610
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