BTF3 is a protein initially identified in HeLa cells that may be involved in the initiation of transcription. Although its specific role in transcription is unclear, BTF3 can form a stable complex with RNA polymerase II. Recently, BTF3 has also been shown to bind to nascent polypeptide chains. We have cloned a homolog of BTF3 from the fission yeast, Schizosaccharomyces pombe. This homolog, spBTF3, encodes a putative 151 amino acid protein that shares 72% similarity with human BTF3, 73% similarity with the Caenorhabditis elegans homolog and between 52 and 53% similarity with the Saccharomyces cerevisiae homologs, EGD1 and BTT1.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
BTF3 is a protein initially identified in HeLa cells that may be involved in the initiation of transcription. Although its specific role in transcription is unclear, BTF3 can form a stable complex with RNA polymerase II. Recently, BTF3 has also been shown to bind to nascent polypeptide chains. We have cloned a homolog of BTF3 from the fission yeast, Schizosaccharomyces pombe. This homolog, spBTF3, encodes a putative 151 amino acid protein that shares 72% similarity with human BTF3, 73% similarity with the Caenorhabditis elegans homolog and between 52 and 53% similarity with the Saccharomyces cerevisiae homologs, EGD1 and BTT1.
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| skos:exactMatch | |
| uniprot:name |
Biochim. Biophys. Acta
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| uniprot:author |
Callaci J.,
Potashkin J.,
Wentz-Hunter K.
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| uniprot:date |
1996
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| uniprot:pages |
182-184
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| uniprot:title |
BTF3 is evolutionarily conserved in fission yeast.
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| uniprot:volume |
1308
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| dc-term:identifier |
doi:10.1016/0167-4781(96)00114-5
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