A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.
| Predicate | Object |
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| rdf:type | |
| rdfs:comment |
A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.
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| skos:exactMatch | |
| uniprot:name |
Cancer Res.
|
| uniprot:author |
Lister T.A.,
Meerabux J.,
Roebroek A.J.M.,
Van de Ven W.J.M.,
Yaspo M.-L.,
Young B.D.
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| uniprot:date |
1996
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| uniprot:pages |
448-451
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| uniprot:title |
A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.
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| uniprot:volume |
56
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