The amino acid sequence of a rat opioid receptor, designated as ROR-D, has been deduced by cloning and sequencing the cDNA. The ROR-D expressed from the cDNA exhibits high affinities for ligands selective for the opioid receptor kappa-subtype and low affinities for ligands selective for the delta- and mu-subtypes. RNA blot hybridization analysis indicated that ROR-D mRNA is distributed in cerebrum and brainstem but not in cerebellum.
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| rdf:type | |
| rdfs:comment |
The amino acid sequence of a rat opioid receptor, designated as ROR-D, has been deduced by cloning and sequencing the cDNA. The ROR-D expressed from the cDNA exhibits high affinities for ligands selective for the opioid receptor kappa-subtype and low affinities for ligands selective for the delta- and mu-subtypes. RNA blot hybridization analysis indicated that ROR-D mRNA is distributed in cerebrum and brainstem but not in cerebellum.
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| skos:exactMatch | |
| uniprot:name |
FEBS Lett.
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| uniprot:author |
Fukuda K.,
Kato S.,
Mori K.,
Nishi M.,
Takeshima H.
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| uniprot:date |
1993
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| uniprot:pages |
77-80
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| uniprot:title |
cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands.
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| uniprot:volume |
330
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| dc-term:identifier |
doi:10.1016/0014-5793(93)80923-I
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