The nucleotide sequence of a 25.7 kilobase Drosophila melanogaster genomic DNA segment containing a gene for a ryanodine receptor/calcium release channel homologue has been determined. Computer analysis and partial cDNA cloning revealed 26 exons comprising the protein-coding sequence in this gene. The predicted protein is homologous in amino acid sequence and shares characteristic structural features with the mammalian ryanodine receptors. In blot hybridization analysis, a approximately 16 kilobase RNA species was identified abundantly in a 6-12 h embryo as the transcript from this gene. In situ hybridization to polytene chromosomes indicated that this gene locates at band position 44F on the second chromosome.
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| rdf:type | |
| rdfs:comment |
The nucleotide sequence of a 25.7 kilobase Drosophila melanogaster genomic DNA segment containing a gene for a ryanodine receptor/calcium release channel homologue has been determined. Computer analysis and partial cDNA cloning revealed 26 exons comprising the protein-coding sequence in this gene. The predicted protein is homologous in amino acid sequence and shares characteristic structural features with the mammalian ryanodine receptors. In blot hybridization analysis, a approximately 16 kilobase RNA species was identified abundantly in a 6-12 h embryo as the transcript from this gene. In situ hybridization to polytene chromosomes indicated that this gene locates at band position 44F on the second chromosome.
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| skos:exactMatch | |
| uniprot:name |
FEBS Lett.
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| uniprot:author |
Hosoya T.,
Hotta Y.,
Iwabe N.,
Masai I.,
Miyata T.,
Nishi M.,
Takeshima H.
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| uniprot:date |
1994
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| uniprot:pages |
81-87
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| uniprot:title |
Isolation and characterization of a gene for a ryanodine receptor/calcium release channel in Drosophila melanogaster.
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| uniprot:volume |
337
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| dc-term:identifier |
doi:10.1016/0014-5793(94)80634-9
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