Through screening of a murine brain cDNA library, we have isolated two brain specific cDNAs encoding highly homologous proteins, named 921-L and 921-S, comprised of 134 amino acids with 80% identity. Immunohistological study with the mAbs raised against the bacterially expressed 921 proteins showed that 921-L protein is distributed at the dendritic region and 921-S at the neuronal somatic surface. Immuno-electron microscopic study revealed that both 921 proteins are localized at the presynaptic terminal, indicating that the 921 proteins are differentially expressed at the dendritic and somatic presynapses.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Through screening of a murine brain cDNA library, we have isolated two brain specific cDNAs encoding highly homologous proteins, named 921-L and 921-S, comprised of 134 amino acids with 80% identity. Immunohistological study with the mAbs raised against the bacterially expressed 921 proteins showed that 921-L protein is distributed at the dendritic region and 921-S at the neuronal somatic surface. Immuno-electron microscopic study revealed that both 921 proteins are localized at the presynaptic terminal, indicating that the 921 proteins are differentially expressed at the dendritic and somatic presynapses.
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| skos:exactMatch | |
| uniprot:name |
FEBS Lett.
|
| uniprot:author |
Fujimoto S.,
Higuchi T.,
Kaba H.,
Matsuda Z.,
Miyata T.,
Ogawa M.,
Okutani F.,
Takahashi S.,
Taniguchi T.,
Yagyu K.,
Yamamoto H.
|
| uniprot:authorsIncomplete |
true
|
| uniprot:date |
1995
|
| uniprot:pages |
455-460
|
| uniprot:title |
Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses.
|
| uniprot:volume |
368
|
| dc-term:identifier |
doi:10.1016/0014-5793(95)00713-J
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