Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
|
| skos:exactMatch | |
| uniprot:name |
Science
|
| uniprot:author |
Dlugosz A.A.,
Hansen L.A.,
Harris R.C.,
Herrup K.,
LaMantia C.,
Lichti U.,
Mourton T.,
Tennenbaum T.,
Threadgill D.W.,
Yee D.
|
| uniprot:authorsIncomplete |
true
|
| uniprot:date |
1995
|
| uniprot:pages |
230-234
|
| uniprot:title |
Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.
|
| uniprot:volume |
269
|
| dc-term:identifier |
doi:10.1126/science.7618084
|