The Drosophila runt gene, which controls early events in embryogenesis, has been shown to have homologues in human and mouse. The human gene on 21q22 is involved in the t(8;21) associated with acute myeloid leukemia. Two mouse runt-like loci encoding DNA-binding proteins have been identified. We report here the isolation and partial sequence of a molecular clone of a third mouse runt-like locus. By using a panel of somatic cell hybrids and interspecific backcross mice, we map the novel locus to the telomeric region of mouse chromosome 4.
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The Drosophila runt gene, which controls early events in embryogenesis, has been shown to have homologues in human and mouse. The human gene on 21q22 is involved in the t(8;21) associated with acute myeloid leukemia. Two mouse runt-like loci encoding DNA-binding proteins have been identified. We report here the isolation and partial sequence of a molecular clone of a third mouse runt-like locus. By using a panel of somatic cell hybrids and interspecific backcross mice, we map the novel locus to the telomeric region of mouse chromosome 4.
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| uniprot:name |
Genomics
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| uniprot:author |
Boyd Y.,
Calabi F.,
Rhodes M.,
Williamson P.
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| uniprot:date |
1995
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| uniprot:pages |
607-610
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| uniprot:title |
Identification and chromosomal mapping of a third mouse runt-like locus.
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| uniprot:volume |
26
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| dc-term:identifier |
doi:10.1016/0888-7543(95)80184-N
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