Signaling molecules with either attractive or repulsive effects on specific growth cones are likely to play a role in guiding axons to their appropriate targets. A chick brain glycoprotein, collapsin, has been shown to be a good candidate for a repulsive guidance cue. We report here the discovery of four new molecules related to collapsin in chick brains. All contain a semaphorin domain. One is structurally very similar to collapsin but is only 50% identical in its amino acid sequence. We have named it collapsin-2. The collapsin-related genes exhibit distinct but overlapping patterns of mRNA expression in the developing spinal cord and the developing visual system. This family of collapsin-related molecules could potentially act as repulsive cues toward specific neuronal populations.
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:comment |
Signaling molecules with either attractive or repulsive effects on specific growth cones are likely to play a role in guiding axons to their appropriate targets. A chick brain glycoprotein, collapsin, has been shown to be a good candidate for a repulsive guidance cue. We report here the discovery of four new molecules related to collapsin in chick brains. All contain a semaphorin domain. One is structurally very similar to collapsin but is only 50% identical in its amino acid sequence. We have named it collapsin-2. The collapsin-related genes exhibit distinct but overlapping patterns of mRNA expression in the developing spinal cord and the developing visual system. This family of collapsin-related molecules could potentially act as repulsive cues toward specific neuronal populations.
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| skos:exactMatch | |
| uniprot:name |
Neuron
|
| uniprot:author |
Chang S.,
Li J.,
Luo Y.,
Raper J.A.,
Renzi M.J.,
Shepherd I.
|
| uniprot:date |
1995
|
| uniprot:pages |
1131-1140
|
| uniprot:title |
A family of molecules related to collapsin in the embryonic chick nervous system.
|
| uniprot:volume |
14
|
| dc-term:identifier |
doi:10.1016/0896-6273(95)90261-9
|